Genomics Cores and Centers

Center for Human Genetics Research (CHGR)
The mission of the Center for Human Genetics Reseach is to decipher the genetic basis of rare and common human traits and to integrate this knowledge into the diagnostics, treatments, and preventions of human disease.

Computational Genomics Core
The objective of the Computational Genomics Core is to provide the software and hardware support for computing activities related to genetics, as well as statistical analysis for human genetics data generated from both microsatellite markers and SNPs. This core, new in July 2005, is the result of a merger between the Bioinformatics Core and the Genetic Data Analysis Core. Bioinformatics support, resources, and expertise are available in storing and managing demographic, clinical, genotypic, microarray, proteomic, and biospecimen data. This core also provides the necessary database structures and development expertise to assist a wide variety of projects.

Genome Technology Core (GTC)
The Genome Technology Core (GTC) offers next-generation DNA sequencing using the Illumina Genome Analyzer II (Solexa). This instrument has the capability of producing up to a gigabase of DNA sequence per run and offers a broad range of scientific applications.

DNA Resources Core
The CHGR/GCRC DNA Resources Core provides services in human DNA extraction, DNA sample banking, genotyping, and other services that support molecular genetics studies.    Most DNA extractions can be performed with our Autopure robot (Gentra Systems), which uses the highly reliable PureGene reagent system and bar-coding for efficient sample handling. 

DNA Sequencing Facility
The DNA Sequencing Facility was created by the merger of the Vanderbilt Ingram Cancer Center DNA core with the Division of Genetic Medicine's sequencing operations. The facility has been under the direction of Alfred L. George, Jr. M.D. since May 2002. The purpose of the DNA Sequencing Facility is to provide academic researchers within and outside the Vanderbilt community high quality DNA sequencing at minimal cost.

Vanderbilt Microarray Shared Resource (VMSE)
The VMSR is primarily supported by the Vanderbilt-Ingram Cancer Center, the Vanderbilt Digestive Disease Research Center, and the Vanderbilt Vision Research Center. The generous support of these centers has allowed the VMSR to continually adopt the most up-to-date methods and technologies available, ensuring all investigators have access to comprehensive and state of the art gene expression and bioinformatic services in the VMSR.